Cookies help us deliver our services. By using our services, you agree to our use of cookies. Learn more
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.

Essential

Cookie list: CART CATEGORY_INFO COMPARE CUSTOMER CUSTOMER_AUTH CUSTOMER_INFO

Marketing

Cookie list: CUSTOMER_SEGMENT_IDS EXTERNAL_NO_CACHE FRONTEND GUEST-VIEW LAST_CATEGORY LAST_PRODUCT NEWMESSAGE NO_CACHE PERSISTENT_SHOPPING_CART

Google Analytics

Cookie list: RECENTLYCOMPARED STF STORE USER_ALLOWED_SAVE_COOKIE VIEWED_PRODUCT_IDS WISHLIST WISHLIST_CNT GA
  • Sign In
  • Create an Account
Toggle Nav
Menu
Account
My Cart
Search

Nicholas D. Tomko, Ph.D.

Scientist, Contract Research Laboratory

Personal Statement
I was in graduate school when the immune checkpoint inhibitors demonstrated their amazing efficacy and the Nobel Prize was awarded to Dr. James Alison and Dr. Tasuku Honjo for their discovery of “cancer therapy by inhibition of negative immune regulation.” At the time, my Ph.D. mentor had shown the effects of lipid oxidation products on the complement pathway and toll-like receptors within the eye; and my research had found that a specific lipid oxidation product induced the migration of glioblastoma cancer stem cells. Our focus on the innate immune system and the resurgence of immunology led me to joining CTL because of their pioneering work in ELISPOT that enables us to monitor the immune system’s function with unparalleled sensitivity. The contract research laboratory works with pharmaceutical and biotechnology companies in the development of new medicines from preclinical stages through the clinical trials and commercialization. Within this department, I have witnessed our technology’s effect on monitoring the immune system in a vast array of therapeutic treatments ranging from gene therapies and cancer to HIV and the SARS-CoV-2 pandemic.

Education and Training
  • B.S. 2011, Forensic Science and Chemistry, Eastern Kentucky University
  • Ph.D., 2019, Biological Chemistry, Case Western Reserve University
Publications
  1. Tomko, N., Kluever, M., Wu, C., Zhu, J., Wang, Y., Salomon, R.G. 4-Hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of brain cancer cell invasiveness that may contribute to the failure of anti-angiogenic therapies. Free Radic. Biol. Med. 2020 Jan; 146:234-256.
  2. Liu, Y., Zhang, Y., Wu, C., Zhu, J., Wang, C., Tomko, N., Linetsky, M.D., Salomon, R.G., Ramos-Estebanez, C., Wang, Y., Yu, X. High-Resolution Dynamic Oxygen-17 MR Imaging of Mouse Brain with Golden-Ration-Based Radial Sampling and K-Space-Weighted Image Reconstruction. Magn Reson Med 2018 Jan; 79(1):256-263.
  3. Wu, C., Wang, X., Tomko, N., Zhu, J., Wang, W.R., Zhu, J., Wang, Y., Salomon, R.G. 2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth. Anti-Cancer Agents in Med Chem. 2017;17(6):813-820.
Patents
  1. Salomon, R.G., Crabb, J.W., Cui, Y., Tomko, N. 2018. Anti-CEP antibody or fragment thereof. U.S. Patent 9,957,333, filed April 17, 2015, and issued May 1, 2018.