• Sign In
  • Create an Account
Toggle Nav
Menu
Account
My Cart

Andrea Maul-Pavicic, Ph.D.

Senior Staff Scientist

Personal Statement
Highly experienced biologist with a great passion for and a strong expertise in immunology, mainly the investigation of antibody glycosylation patterns in the context of autoimmunity and inflammation. Extensive experience in clinical and therapeutic research including stem cell biology, infectious diseases, immunodeficiencies, cytotoxic defects, characterization of B cells and plasma cells known for their role in antibody production and immunological memory.

Major goals:
  • Discovering new scientific and therapeutic approaches in order to ameliorate inflammatory processes in patients suffering from autoimmune and infectious diseases.
  • Monitoring changes in (pathogenic) antibody glycosylation patterns in order to predict upcoming flares in inflammatory diseases.
Education and Training
  • Studies of Molecular biology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany
  • M.Sc. in Molecular biology, German Cancer Research Center, Heidelberg, Germany
  • Ph.D. in Molecular biology, German Cancer Research Center, Heidelberg, Germany
  • Senior Scientist (2012-2021), Center for Chronic Immunodeficiency and Department of Rheumatology and Clinical Immunology, Medical Center- University of Freiburg, Freiburg, Germany
  • Post-doctoral position, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg and Faculty of Medicine Freiburg, Freiburg, Germany
  • Post-doctoral position, Center of Clinical Research, Department of Molecular Genetics of Immunodeficiencies, Freiburg, Germany
  • Post-doctoral position, Max-Planck-Institute of Immunobiology, Department of Molecular Immunology, Freiburg, Germany
  • Post-doctoral position, German Cancer Research Center, Heidelberg, Germany
Publications
  1. Jakob Ankerhold & Sebastian Giese & Philipp Kolb, Andrea Maul-Pavicic, Nathalie Göppert, Kevin Ciminski, Clemens Kreutz, Achim Lother, Ulrich Salzer, Wolfgang Bildl, Tim Welsink, Nils G. Morgenthaler, Andrea Busse Grawitz, Daniela Huzly, Martin Schwemmle, Hartmut Hengel, Valeria Falcone. Circulating immune complexes drive immunopathology in COVID-19. bioRxiv preprint this version posted August 4, 2021.
  2. Haizhang Chen, Andrea Maul-Pavicic, Martin Holzer, Ulrich Salzer, Nina Chevalier, Reinhard E. Voll, Hartmut Hengel & Philipp Kolb. FcγR responses to soluble immune complexes of varying size: A scalable cell-based reporter system. bioRxiv preprint this version posted November 11, 2020.
  3. Lederer AK, Maul-Pavicic A, Hannibal L, Hettich M, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Sehnert B, Salzer U, Klein R, Voll RE, Samstag Y, Huber R. Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids - A randomized, controlled trial. Clin Nutr. 2020 Nov; 39(11):3241-3250.
  4. Lederer AK, Hannibal L, Hettich M, Behringer S, Spiekerkoetter U, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Simmet T, Schmiech M, Maul-Pavicic A, Samstag Y, Huber R. Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants. Nutrients. 2019 Nov 18;11(11):2815. doi: 10.3390/nu11112815. PMID: 31752105
  5. Schaffer S, Maul-Pavicic A, Voll RE, Chevalier N. Optimized isolation of renal plasma cells for flow cytometric analysis. J Immunol Methods. 2019 Nov;474:112628. doi: 10.1016/j.jim.2019.06.019. Epub 2019 Jun 26. PMID: 31254500
  6. Sassi A, Lazaroski S, Wu G, Haslam SM, Fliegauf M, Mellouli F, Patiroglu T, Unal E, Ozdemir MA, Jouhadi Z, Khadir K, Ben-Khemis L, Ben-Ali M, Ben-Mustapha I, Borchani L, Pfeifer D, Jakob T, Khemiri M, Asplund AC, Gustafsson MO, Lundin KE, Falk-Sörqvist E, Moens LN, Gungor HE, Engelhardt KR, Dziadzio M, Stauss H, Fleckenstein B, Meier R, Prayitno K, Maul-Pavicic A, Schaffer S, Rakhmanov M, Henneke P, Kraus H, Eibel H, Kölsch U, Nadifi S, Nilsson M, Bejaoui M, Schäffer AA, Smith CI, Dell A, Barbouche MR, Grimbacher B. Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.J Allergy Clin Immunol. 2014 May;133(5):1410-9, 1419.e1-13. doi: 10.1016/j.jaci.2014.02.025. Epub 2014 Apr 1.
  7. Jessen B, Bode SF, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl WA, Gochuico BR, Griese M, Griffiths G, Janka G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford AD, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu GT, Zieger B, Zur Stadt U, Aichele P, Ehl S. The risk of hemophagocyticlymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood. 2013 Apr 11;121(15):2943-51. doi: 10.1182/blood-2012-10-463166. Epub 2013 Feb 12.
  8. Lehmberg K, Pink I, Eulenburg C, Beutel K, Maul-Pavicic A, Janka G. Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis. J Pediatr. 2013 Jun;162(6):1245-51. doi: 10.1016/j.jpeds.2012.11.081. Epub 2013 Jan 17.
  9. Kurnik K, Bartsch I, Maul-Pavicic A, Ehl S, Sandrock-Lang K, Bidlingmaier C, Rombach N, Busse A, Belohradsky BH, Müller-Höcker J, Aslanidis C, Schmitz G, Zieger B. Novel mutation in Hermansky-Pudlak syndrome type 2 with mild immunological phenotype. Platelets. 2013;24(7):538-43. doi: 10.3109/09537104.2012.741275. Epub 2012 Dec 5.
  10. Bode SF, Lehmberg K, Maul-Pavicic A, Vraetz T, Janka G, Stadt UZ, Ehl S. Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis. Arthritis Res Ther. 2012 Jun 8;14(3):213. doi: 10.1186/ar3843. Review.
  11. Pagel J, Beutel K, Lehmberg K, Koch F, Maul-Pavicic A, Rohlfs AK, Al-Jefri A, Beier R, Bomme Ousager L, Ehlert K, Gross-Wieltsch U, Jorch N, Kremens B, Pekrun A, Sparber-Sauer M, Mejstrikova E, Wawer A, Ehl S, zur Stadt U, Janka G. Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5). Blood. 2012 Jun 21;119(25):6016-24. doi: 10.1182/blood-2011-12-398958. Epub 2012 Mar 26.
  12. Bryceson YT & Pende D & Maul-Pavicic A & Gilmour KC, Ufheil H, Vraetz T, Chiang SC, Marcenaro S, Meazza R, Bondzio I, Walshe D, Janka G, Lehmberg K, Beutel K, zur Stadt U, Binder N, Arico M, Moretta L, Henter JI, Ehl S. A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. Blood. 2012 Mar 22;119(12):2754-63. doi: 10.1182/blood-2011-08-374199. Epub 2012 Jan 31.
  13. Fuchs S, Rensing-Ehl A, Speckmann C, Bengsch B, Schmitt-Graeff A, Bondzio I, Maul-Pavicic A, Bass T, Vraetz T, Strahm B, Ankermann T, Benson M, Caliebe A, Fölster-Holst R, Kaiser P, Thimme R, Schamel WW, Schwarz K, Feske S, Ehl S. Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol. 2012 Feb 1;188(3):1523-33. doi: 10.4049/jimmunol.1102507. Epub 2011 Dec 21.
  14. Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Graeff A, Aichele P, Zur Stadt U, Schwarz K, Ehl S. Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood. 2011 Oct 27;118(17):4620-9. doi: 10.1182/blood-2011-05-356113. Epub 2011 Aug 30.
  15. Kaya Z, Ehl S, Albayrak M, Maul-Pavicic A, Schwarz K, Kocak U, Ergun MA, Gursel T. A novel single point mutation of the LYST gene in two siblings with different phenotypic features of Chediak Higashi syndrome. Pediatr Blood Cancer. 2011 Jul 1;56(7):1136-9. doi: 10.1002/pbc.22878. Epub 2011 Feb 4.
  16. Maul-Pavicic A, Chiang SC, Rensing-Ehl A, Jessen B, Fauriat C, Wood SM, Sjöqvist S, Hufnagel M, Schulze I, Bass T, Schamel WW, Fuchs S, Pircher H, McCarl CA, Mikoshiba K, Schwarz K, Feske S, Bryceson YT, Ehl S. ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3324-9. doi: 10.1073/pnas.1013285108. Epub 2011 Feb 7.