B-Poly-SE™ Polyclonal B cell Stimulator

Memory B cells exist in a quiescent state in the absence of recent antigen encounter and importantly do not secrete their individual BCR as soluble antibody. Therefore, polyclonal stimulation of resting memory B cell is required for their measurement using ELISPOT or FluoroSpot (collectively ImmunoSpot®). CTL Human B-Poly-SE™ has been shown to promote polyclonal stimulation and differentiation of B cells into antibody-secreting cells (ASC). Most notably, B-Poly-SE™ inhibits differentiation of naïve B cells expressing an IgM+ B cell receptor and can elicit production of all Ig classes and IgG subclasses; including IgE.

Concentration: CTL B-Poly-SE™ (Human) - 333x

Catalog #CTL-hBPOLYSE-35, CTL-hBPOLYSE-160