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Sylwia Chelstowska, Ph.D.

Scientist, CRO

Personal Statement
The immune system plays a major role in several illnesses such as infectious diseases, auto-immune diseases, and cancer. Therefore, immune monitoring is important for the development of vaccines and immune-oncological therapies. Immunological techniques like ELISPOT, ELISA or flow cytometry are great tools for monitoring the immune response to vaccines or therapies. I have found at CTL a perfect place to improve my knowledge and technical experience in immunology.

Education
  • Case Western Reserve University, USA – Post-doctoral Fellowship
  • Military Institute of Medicine, Poland - Ph.D., Medical Science/Immunology
  • Medical University of Warsaw, Poland – Medical Analytics
  • University of Warsaw, Poland - M.Sc., Biology/Biotechnology
Publications
  1. Widjaja-Adhi MA., Silvaroli J., Chelstowska S., Trischman T., Bederman I., Sayegh R., Golczak M. “Deficiency in Acyl-CaA: Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters” The FASEB Journal, (2020), 34 (10), 13792-13808.
  2. Silvaroli J., Widjaja-Adhi MA., Trischman T., Chelstowska S., Horwitz S., Banerjee S., Kiser P., Blaner WS., Golczak M. "Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1" ACS Chemical Biology, (2019) 14 (3), 434-448.
  3. Chelstowska S., Widjaja-Adhi MA, Silvaroli JA, Golczak M “Impact of LCA-associated E14L LRAT mutation on protein stability and retinoid homeostasis” Biochemistry, (2017) 56 (34), 4489-4499.
  4. Arne JM, Widjaja-Adhi MA, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S., Moiseenkova-Bell VY, Golczak M. „Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2).” J Lipid Res. (2017) Jan 17, 58 (4), 719-730.
  5. Chelstowska S., Widjaja-Adhi M.K., Silvaroli J., Golczak M. „Molecular Basis for Vitamin A Uptake and Storage in Vertebrates” Nutrients (2016) 8, 676.
  6. Silvaroli J. Arne J. Chelstowska S. Kiser P. Banerjee S. Golczak M.” Ligand Binding Induces Conformational Changes in Human Cellular Retinol-Binding Protein 1 (CRBP1) revealed by atomic resolution crystal structures” J. Biol. Chem (2016) 291 (16), 8528-8540.
  7. Chelstowska S. Płusa T. “Znaczenie czynników zewnątrzpochodnych w etiopatogenezie sarkoidozy.” Internat. Rev. Allergol. Clin. Immunol. Family Med. (2015) Vol.21, No. 3.
  8. Plusa T. Chelstowska S. „CD34+ progenitor cells in pulmonary sarcoidosis” Pol. Merkur. Lek (2015) XXXVIII/227: 250-253.
  9. Chelstowska S. Plusa T. „IGRA and tuberculin skin test in patients with sarcoidosis.” Int. Rev. Allergol. Clin. Immunol. Family Med. (2015) XXI/1: 017-020.
  10. Targowski T. Chelstowska S. Płusa T. „Tuberculin skin test and interferon-γ release assay in detection of latent tuberculosis infection among Polish health care workers” Int. Rev. of the Armed Forces Med. Serv. (2015) Vol.88, No 3, 34-40.
  11. Targowski T., Chelstowska S., Plusa T. „IGRA as a predictive factor of silent pulmonary changes in individuals following exposure to tuberculosis.” Lung. (2014) Dec;192(6):869-74.
  12. Chelstowska S. „Aktualne poglądy dotyczące etiologii sarkoidozy.” Internat. Rev. Allergol. Clin. Immunol. Family Med. (2014) Vol. 20, No. 2.
  13. Chelstowska S. Wajs J. Rzepecki P. „Atypowa morfologia limfocytów: dystrybucja skspresji antygenu CD38 na komórkach przewlekłej białaczki limfocytowej.” Internat. Rev. Allergol. Clin. Immunol. Family Med. (2014) Vol. 20, No. 1.
  14. Targowski T. Chelstowska S. Płusa T. „Tuberculin skin test and interferon-gamma release assay in detection of latent tuberculosis infection among Polish healthcare workers” Pol Arch Med Wewn. 2014, on line: December 16 (2013).
  15. Chelstowska S. Wajs J. Rzepecki P. Płusa T. „Rola fibrocytów w procesach włóknienia płuc” Pol Merk. Lek. (2014), Vol. XXXVI, No. 211.
  16. Chelstowska S. Wajs J. Rzepecki P. Płusa T. „The role of fibrocytes in pulmonary fibrosis” Internat. Rev. Allergol. Clin. Immunol. Family Med. (2013) Vol.19, No. 4.
  17. Łoniewska-Lwowska A. Chelstowska S. Zagórski-Ostoja W. Pałucha A. „Elements regulating Potato Leafroll virus sgRNA1 translation are located within the coding sequences of the coat protein and read-trough domain.” Acta Biochim. Pol. (2009) 56 (4):619-25.